ADAMTS proteoglycanases downregulation with impaired oocyte quality in PCOS

O-24: Increased Homocysteinein PCOS Affects Oocyte and Embryo Quality

Background: The biochemical characteristics of the follicular fluid (FF) play essential role in oocyte quality, the subsequent fertilization potential and embryo development. The oocyte quality and metabolism largely depends on follicular microenvironment. Present study aimed to investigate the relationship between oocyte quality and FF homocysteine (Hcy) level in women undergoing to IVF treatm...

O-26: Association of Follicular Fluid Endocrine Changes with Oocyte Morphology and Quality in PCOS Patients Undergoing Metformin and N-Acetylcysteine Treatment

Background: Polycystic ovary syndrome (PCOS) is a common cause of infertility often responsive to treatment with oral ovulation induction agents. PCOS patients are typically characterized by producing an increased number of oocytes that they are often of poor quality, leading to lower fertilization, cleavage and implantation rates. Recently data involve functional associations between endocrine...

Impaired receptivity and decidualization in DHEA-induced PCOS mice

Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low with a high rate of early clinical pregnancy loss, suggesting a problem in uterine receptivity. Usin...

Upregulation of ADAMTS-7 and downregulation of COMP are associated with aortic aneurysm

Aortic aneurysm (AA) remains a fatal condition with high rates of morbidity and mortality, and the associated underlying mechanism influencing its pathology remains to be elucidated. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)‑7 has previously been demonstrated to be involved in the pathogenesis of vascular atherosclerosis via degradation of cartilage oligomeric matr...

Chromosomal Abnormality in Men with Impaired Spermatogenesis